Publications

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*corresponding author #undergraduate researcher


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63
Metal-Responsive Regulation of Enzyme Catalysis Using Genetically Encoded Chemical Switches

Zubi, Y. S.; Seki, K.; Li, Y.; Hunt, A.; Liu, B.; Roux, B.*, Jewett, M. C.*, Lewis, J. C.* Nat. Commun. 2022, 13, 1864. Preprint available on ChemRxiv. See peer review here.

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Category: Artificial Metalloenzymes | Biocatalysis | Chemical Biology

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60
Phage-Assisted Continuous Evolution and Selection of Enzymes for Chemical Synthesis

Jones, K. A.; Snodgrass, H. M.; Belsare, K.; Dickinson, B. C.*, Lewis, J. C.* ACS Central Science, 2021, 7, 1581-1590. Preprint available on ChemRxiv.

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Category: Biocatalysis | Chemical Biology

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52
Development of a Split Esterase for Protein–Protein Interaction-Dependent Small-Molecule Activation

Jones, K. A.; Kentala, K.; Beck, M. W.; An, W.; Lippert, A. R.; Lewis, J. C.; Dickinson, B. C.* Development of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation. ACS Central Science, 2019, ASAP.

See the original manuscript at ChemRxiv.

 

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Category: Chemical Biology

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5
Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1

Souers, A. J.; Wodka, D.; Gao, J.; Lewis, J. C.#; Vasudevan, A.; Gentles, R.; Brodjian, S.; Dayton, B.; Ogiela, C. A.; Fry, D.; Hernandez, L. E.; Marsh, K. C.; Collins, C. A.; Kym, P. R. Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg. Med. Chem. Lett. 2004, 14, 4873-4877.

Category: Chemical Biology

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4
Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3

Souers, A. J.; Wodka, D.; Gao, J.; Lewis, J. C.#; Vasudevan, A.; Brodjian, S.; Dayton, B.; Ogiela, C. A.; Fry, D.; Hernandez, L. E.; Marsh, K. C.; Collins, C. A.; Kym, P. R. Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3. Bioorg. Med. Chem. Lett. 2004, 14, 4883-4886.

Category: Chemical Biology

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3
Effects of Bisphosphonates on the Growth of Entamoeba histolytica and Plasmodium Species in Vitro and in Vivo

Ghosh, S.; Chan, J. M. W.#; Lea, C. R.; Meints, G. A.; Lewis, J. C.#; Tovian, Z. S.#; Flessner, R. M.; Loftus, T. C.#; Bruchhaus, I.; Kendrick, H.; Croft, S. L.; Kemp, R. G.; Kobayashi, S.; Nozaki, T.; Oldfield, E.* Effects of Bisphosphonates on the Growth of Entamoeba histolytica and Plasmodium Species in Vitro and in Vivo. J. Med. Chem. 2004, 47, 175-187.

Category: Chemical Biology

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2
A 3D-QSAR/CoMFA Study of the Activity of Bisphosphonates Against Trypanosoma brucei rhodesiense: Farnesyl Pyrophosphate Synthase as a Drug Target and Analysis of Drug Toxicity

Martin, M. B.; Sanders, J. M.; Kendrick, H.; de Luca-Fradley, K.; Yardley, V.; Lewis, J. C.#; Grimley, J. S.#; van Brussel, E. M.#; Olsen, J. R.#; Meints, G. A.; Burzyska, A.; Kararski, P.; Croft, S. L.; Oldfield, E.* A 3D-QSAR/CoMFA Study of the Activity of Bisphosphonates Against Trypanosoma brucei rhodesiense: Farnesyl Pyrophosphate Synthase as a Drug Target and Analysis of Drug Toxicity. J. Med. Chem. 2002, 45, 2904-2914.

Category: Chemical Biology

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1
Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy

Martin, M. B.; Grimley, J. S.#; Lewis, J. C.#; Heath, H. T. III; Bailey, B. N.; Kendrick, H.; Yardley, V.; Caldera, A.; Lira, R.; Urbina, J. A.; Moreno, S. N. J.; Docampo, R.; Croft, S.; Oldfield, E.* Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy. J. Med. Chem. 2001, 44, 909-916.

Category: Chemical Biology

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Patents

3    Coelho, Pedro, S.; Brustad, Eric M.; Arnold, Frances H.; Wang, Z.; Lewis, Jared C. In vivo and in vitro olefin cyclopropanation catalyzed by engineered and chimeric heme enzyme.” PCT Int. Appl. WO2014058744, 2014.

2    Arnold, F. H.; Wong, C.-H.; Mitsuda, Y.; Chen, M. M.; Bennett, C. S.; Greenberg, W. A.; Lewis, J. C.; Bastian, S. Engineered Bacterial Cytochrome P450 Variants for Preparation of Selectively Protected Carbohydrates. Patent No. US 20090124515, 2009.

1    Collins, C. A.; Gao, J.; Kym, P. R.; Lewis, J. C.; Souers, A. J.; Vasudevan, A.; Wodka, D. 2-Aminoquinolones as Melanin Concentrating Hormone Receptor Antagonists. Patent No. WO 2003105850, 2003.