Publications

Google Scholar Citation Index

All Publications  Artificial Metalloenzymes  Biocatalysis  Chemical Biology  Organometallics  Other

*corresponding author #undergraduate researcher


69
First and Second Sphere Interactions Accelerate Non-Native N-Alkylation Catalysis by the Thermostable, Methanol-Tolerant B12-Dependent Enzyme MtaC.

Kumar, A.; Yang, X., Li, J.; Lewis, J. C.* Submitted. Preprint available on ChemRxiv.

Publication Link


68
Expanding the Reactivity of Flavin Dependent Halogenases Toward Olefins via Enantioselective Intramolecular Haloetherification and Chemoenzymatic Oxidative Rearrangements

Jiang, Y.; Mondal, D.; Lewis, J. C.* Submitted. Preprint available on ChemRxiv.

Category: Biocatalysis

Publication Link


67
Non-native Anionic Ligand Binding and Reactivity in Engineered Variants of the Fe(II)- and α-Ketoglutarate-Dependent Oxygenase, SadA

Chan, N. H.; Gomez, C.; Vennelakanti, V.; Du, Q.; Kulik, H. J.*; Lewis, J. C.* Submitted. Preprint available on ChemRxiv.

Category: Biocatalysis

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66
Cobalamin-Mediated Electrocatalytic Reduction of Ethyl Chloroacetate in Dimethylformamide

Gerroll, B. H. R.; Lewis, J. C.; Baker, L. A.* J. Electrochem. Soc. 2022, 169, 055501.

Category: Organometallics

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65
Directed Evolution of Flavin-Dependent Halogenases for Atroposelective Halogenation of 3-Aryl-4(3H)-quinazolinones via Kinetic or Dynamic Kinetic Resolution

Snodgrass, H. M.; Mondal, D.; Lewis, J. C.* Submitted. Preprint available on ChemRxiv.

Category: Biocatalysis

Publication Link


64
Analysis of Laboratory-Evolved Flavin-Dependent Halogenases Affords a Computational Model for Predicting Halogenase Site Selectivity

Andorfer, M. C.; Evans, D.; Yang, S. He, C. Q.; Girlich, A. M.#; Vergara-Coll, J.#; Sukumar, N.; Houk, K. N.*; Lewis, J. C.* Chem. Catal. 2022. Check out the original manuscript on ChemRxiv.

Category: Biocatalysis

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63
Metal-Responsive Regulation of Enzyme Catalysis Using Genetically Encoded Chemical Switches

Zubi, Y. S.; Seki, K.; Li, Y.; Hunt, A.; Liu, B.; Roux, B.*, Jewett, M. C.*, Lewis, J. C.* Nat. Commun. 2022, 13, 1864. Preprint available on ChemRxiv. See peer review here.

Category: Artificial Metalloenzymes | Biocatalysis | Chemical Biology

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62
Controlling the Optical and Catalytic Properties of Artificial Metalloenzyme Photocatalysts Using Chemogenetic Engineering

Zubi, Y. S.; Liu, B.; Gu, Y.; Sahoo, D.; Lewis, J. C.* Chem. Sci. 2022, 13, 1459-1468. Preprint available on ChemRxiv.

Category: Artificial Metalloenzymes

Publication Link


61
Controlling Non-Native B12 Reactivity and Catalysis in the Transcription Factor CarH

Yang, X.; Gerroll, B. H. R.; Jiang, Y.; Kumar, A.; Zubi, Y. S.; Baker, L. A.; Lewis, J. C.* ACS Catal. 2022, 12, 935-942. Preprint available on ChemRxiv.

Category: Biocatalysis | Organometallics

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60
Phage-Assisted Continuous Evolution and Selection of Enzymes for Chemical Synthesis

Jones, K. A.; Snodgrass, H. M.; Belsare, K.; Dickinson, B. C.*, Lewis, J. C.* ACS Central Science, 2021, 7, 1581-1590. Preprint available on ChemRxiv.

Category: Biocatalysis | Chemical Biology

Publication Link


59
Engineering Dirhodium Artificial Metalloenzymes for Diazo Coupling Cascade Reactions

Upp, D. M.; Huang, R; Li, Y.; Bultman, M. J.#; Roux, B.*, Lewis, J. C.* Angew. Chem. Int. Ed. 2021, 60, 2-7. You can read the original manuscript on ChemRxiv.

Category: Artificial Metalloenzymes

Publication Link


58
Flavin-Dependent Halogenases Catalyze Enantioselective Olefin Halocyclization.

Dibyendu Mondal, Brian F. Fisher, Yuhua Jiang, Jared C. Lewis*. Flavin-Dependent Halogenases Catalyze Enantioselective Olefin Halocyclization. Nat. Commun. 2021, 3268. You can read the original manuscript at ChemRxiv. See peer review discussion here.

Category: Biocatalysis

Publication Link


57
Insight into the Scope and Mechanism for Transmetallation of Hydrocarbyl Ligands on Complexes Relevant to C-H Activation

Natalie Chan, Joseph J. Gair, Michael Roy#, Yehao Qiu#, Duo-Sheng Wang, Landon J. Durak, Liwei Chen#, Alexander S. Filatov, Jared C. Lewis*. Insight into the Scope and Mechanism for Transmetallation of Hydrocarbyl Ligands on Complexes Relevant to C-H Activation. Organometallics, 2021, 40, 6-10. You can read the originally submitted manuscript at ChemRxiv.

Category: Organometallics

Publication Link


56
Catalytic Behavior of Mono-N-Protected Amino Acid Ligands in Ligand-Accelerated C–H Activation by Palladium(II)

Salazar, C. A.; Gair, J. J.; Flesch, K. N.; Guzei, I. A.; Lewis, J. C.; Stahl, S. S.* Catalytic Behavior of Mono-N-Protected Amino-Acid Ligands in Ligand-Accelerated C-H Activation by Palladium(II). Angew. Chem. Int. Ed. 2020, 59, 10873-10877.

Category: Organometallics

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55
A High-throughput Method for Directed Evolution of NAD(P)+ dependent Dehydrogenases for the Reduction of Biomimetic Nicotinamide Analogues

Huang, R.; Chen, H.; Upp, D. M.; Lewis, J. C.; Zhang, Y.-H. P. J.* A High-throughput Method for Directed Evolution of NAD(P)+-dependent Dehydrogenases for the Reduction of Biomimetic Nicotinamide Analogues. ACS Catalysis, 2019, 9, 11709.

Category: Biocatalysis

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54
Di-Palladium Complexes are Active Catalysts for Mono-N-Protected Amino Acid Accelerated Enantioselective C-H Functionalization

Gair, J. J.; Haines, B. E.; Filatov, A. S.; Musaev, D. G.*; Lewis, J. C.* Di-Palladium Complexes are Active Catalysts for Mono-N-Protected Amino Acid Accelerated Enantioselective C-H Functionalization. ACS Catalysis, 2019, 9, 11386-11397. This project originated from efforts to incorporate a Pd-MPAA catalyst into a protein scaffold to generate an ArM. Establishing the identity of such a catalyst proved far more difficult than we expected! The original manuscript, available at ChemRxiv, notes this origin story, which had to be removed during peer review.

Category: Organometallics

Publication Link


53
Site-Selective C-H Halogenation using Flavin-Dependent Halogenases Identified via Family-Wide Activity Profiling

Fisher, B. F.; Snodgrass, H. M.; Jones, K. A.; Andorfer, M. C.; Lewis, J. C.* Site-Selective C-H Halogenation using Flavin-Dependent Halogenases Identified via Family-Wide Activity Profiling. ACS Central Science, 2019, 11, 1184. See the original manuscript at ChemRxiv.

Category: Biocatalysis

Publication Link


52
Development of a Split Esterase for Protein–Protein Interaction-Dependent Small-Molecule Activation

Jones, K. A.; Kentala, K.; Beck, M. W.; An, W.; Lippert, A. R.; Lewis, J. C.; Dickinson, B. C.* Development of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation. ACS Central Science, 2019, ASAP.

See the original manuscript at ChemRxiv.

 

Category: Chemical Biology

Publication Link


51
Beyond the Second Coordination Sphere: Engineering Dirhodium Artificial Metalloenzymes to Enable Protein Control of Transition Metal Catalysis

Lewis, J. C.* Beyond the Second Coordination Sphere: Engineering Dirhodium Artificial Metalloenzymes to Enable Protein Control of Transition Metal Catalysis. Accounts of Chemical Research. 2019, 52, 576-584.

This manuscript was an invited contribution to a special issue of Accounts of Chemical Research on artificial metalloenzyme catalysis and non-native reactions catalyzed by natural metalloenzymes. Check out the rest of the excellent articles here!

Category: Artificial Metalloenzymes

Publication Link


50
Synthesis, Characterization, and Theoretical Investigation of a Transition State Analogue for Proton Transfer During C-H Activation by a Rhodium-Pincer Complex

Gair, J. J.; Qiu, Y.#; Khade, R. L.; Chan, N.; Filatov, A. S.; Zhang, Y.*; Lewis, J. C.* A Heterobimetallic Isolobal Transition State Analogue for Proton Transfer During C-H Activation by a Rh-Pincer Complex. Organometallics, 2019, 38, 1407.

Category: Organometallics

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49
Pyrococcus furiosus Prolyl Oligopeptidase: A Dynamic Supramolecular Host for Peptidase and Dirhodium Catalysis

Ellis-Guardiola, K.; Rui, H.; Beckner, R.;# Srivastava, P.; Sukumar, N.*; Roux, B.*; Lewis, J. C.* Crystal Structure and Conformational Dynamics of Pyrococcus furiosus Prolyl Oligopeptidase. Biochemistry2019, 58, 1616.

The studies detailed in this manuscript were originally reported on ChemRxiv. The ChemRxiv manuscript detailed how the large scale conformational dynamics outlined in the Biochemistry paper can be used to rationalize the specificity of dirhodium ArMs created from the POP scaffold for cyclopropanation over water O-H insertion. Unfortunately, we were unable to convince reviewers of the latter point, but you can still read about it on ChemRxiv here!

Category: Artificial Metalloenzymes | Biocatalysis

Publication Link


48
Enantioselective Desymmetrization of Methylenedianilines via Enzyme-Catalyzed Remote Halogenation

Payne, J. T.; Butkovich, P.; Kunze, K. N.#; Park, H.-J.; Yang, D.-S.; Lewis, J. C.* Enantioselective Desymmetrization of Methylenedianilines via Enzyme-Catalyzed Remote Halogenation. J. Am. Chem. Soc. 2018, 140, 546-549.

Category: Biocatalysis

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47
Evolving Artificial Metalloenzyme Selectivity via Random Mutagenesis

Yang, H.; Swartz, A. M.; Srivastava, P.; Ellis-Guardiola, K.; Park, H. J.; Upp, D.; Belsare, K.; Lee, G.; Zhang, C.; Moellering, R. E.; Lewis, J. C.* Evolving Artificial Metalloenzyme Selectivity via Random Mutagenesis. Nat. Chem. 2018, 10, 318-324.

Category: Artificial Metalloenzymes

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46
Preparation of Artificial Metalloenzymes. In Artificial Metalloenzymes and MetalloDNAzymes in Catalysis. From Design to Applications

Ellis-Guardiola, K.; Lewis, J. C.* Preparation of Artificial Metalloenzymes. In Artificial Metalloenzymes and MetalloDNAzymes in Catalysis. From Design to Applications; Diégues, M.; Bäckvall, J.-E.; Pàmies, O., Eds.; 2018, Wiley-VCH.

Category: Artificial Metalloenzymes

Publication Link


45
Understanding and Improving the Activity of Flavin Dependent Halogenases via Random and Targeted Mutagenesis

Andorfer, M. C.; Lewis, J. C.* Understanding and Improving the Activity of Flavin Dependent Halogenases via Random and Targeted Mutagenesis. Ann. Rev. Biochem. 2018, 87, 159-185.

Category: Biocatalysis

Publication Link


44
(PNP)Rh complexes: Improved C-H Activation, Expanded Reaction Scope, and Catalytic Direct Arylation

Gair, J. J.; Qiu, Y.#; Chan, N.; Filatov, A. S.; Lewis, J. C.* (PNP)Rh complexes: Improved C-H Activation, Expanded Reaction Scope, and Catalytic Direct Arylation. Organometallics, 2017, 36, 4699-4706.

Category: Organometallics

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43
Artificial Metalloenzymes: Reaction Scope and Optimization Strategies

Kohler, V.; Schwizer, F.; Okamoto, Y.; Lebrun, V.; Reuter, R.; Pellizzoni, M. M.; Heinisch, T.; Gu, Yifan; Lewis, J. C.*; Ward, T. R.* Artificial Metalloenzymes: Reaction Scope and Optimization Strategies. Chemical Reviews, 2017, 118, 142-231.

Category: Artificial Metalloenzymes

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42
Aromatic Halogenation Using Bifunctional Flavin Reductase-Halogenase Fusion Enzymes

Andorfer, M. C.; Belsare, K. D.; Girlich, A. M.#; Lewis, J. C.* Aromatic Halogenation Using Bifunctional Flavin Reductase-Halogenase Fusion Enzymes.  ChemBioChem, 2017, 18, 2099-2103.

Category: Biocatalysis

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41
Mono-N-Protected Amino Acid Ligands Stabilize Dimeric Palladium(II) Complexes of Importance to C-H Functionalization

Gair, J. J.; Haines, B. E.; Filatov, A. S.; Musaev, D. G.*; Lewis, J. C.* Mono-N-Protected Amino Acid Ligands Stabilize Dimeric Palladium(II) Complexes of Importance to C-H Functionalization. Chemical Science, 2017, 8, 5746-5756.

Category: Organometallics

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40
Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling

Andorfer, M. C.; Grob, J. E.; Hajdin, C. E.; Chael, J. R.#; Siuti, P.; Lilly, J.; Tan, K. L.*; Lewis, J. C.* Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling. ACS Catalysis. 2017, 7, 1897-1904.

Category: Biocatalysis

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39
A Simple Combinatorial Codon Mutagenesis Method for Targeted Protein Engineering

Belsare, K.; Andorfer, M. C.; Cardenas, F.#; Chael, J. R.#; Park, H. J.; Lewis, J. C.* A Simple Combinatorial Codon Mutagenesis Method for Targeted Protein Engineering. ACS Synth. Biol. 2017, 6, 416-420.

Category: Biocatalysis

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38
Selective C-H Bond Functionalization Using Repurposed or Artificial Metalloenzymes

Upp, D. M.; Lewis, J. C.* Selective C-H Bond Functionalization Using Repurposed or Artificial Metalloenzymes. Curr. Opin. Chem. Biol. 2017, 37, 48-55.

Category: Artificial Metalloenzymes

Publication Link


37
Engineering Flavin-Dependent Halogenases

Payne, J. T.; Andorfer, M. C.; Lewis, J. C.* Engineering Flavin-Dependent Halogenases. Meth. Enz. 2016, 575, 93-126.

Category: Biocatalysis

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36
Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds

Andorfer, M. C.; Park, H. J.; Vergara-Coll, J.#; Lewis, J. C.* Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds. Chem. Sci. 2016, 7, 3720-3729.

Category: Biocatalysis

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35
Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization

Durak, L. J.; Payne, J. T.; Lewis, J. C.* Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization. ACS Catal. 2016, 6, 1451-1454.

Category: Biocatalysis

Publication Link


34
Engineering a Dirhodium Artificial Metalloenzyme for Selective Olefin Cyclopropanation

Srivastava, P.; Yang, H.; Ellis-Guardiola, K.; Lewis, J. C.* Engineering a Dirhodium Artificial Metalloenzyme for Selective Olefin Cyclopropanation. Nat. Commun. 2015, 6, 7789.

Category: Artificial Metalloenzymes

Publication Link


33
Preparation, Characterization, and Reactivity of a Photocatalytic Artificial Enzyme

Gu, Y.; Ellis-Guardiola, K.; Srivastava, P.; Lewis, J. C.* Preparation, Characterization, and Reactivity of a Photocatalytic Artificial Enzyme. ChemBioChem. 2015.

Category: Artificial Metalloenzymes

Publication Link


32
Directed Evolution of RebH for Site Selective Halogenation of Large, Biologically Active Molecules

Payne, J. T.; Poor, C. B.; Lewis, J. C.* Directed Evolution of RebH for Site Selective Halogenation of Large, Biologically Active Molecules. Angew. Chem. Int. Ed. 2015, 54, 4226.

See a Synfacts comment here.

Category: Biocatalysis

Publication Link


31
Metallopeptide Catalysts and Artificial Metalloenzymes Containing Unnatural Amino Acids

Lewis, J. C.* Metallopeptide Catalysts and Artificial Metalloenzymes Containing Unnatural Amino Acids. Curr. Opin. Chem. Biol. 2015, 25, 27-35.

Category: Artificial Metalloenzymes

Publication Link


30
Improving the Stability of the FAD-Dependent Halogenase RebH Using Directed Evolution

Poor, C. B.; Andorfer, M. C.; Lewis, J. C.* Improving the Stability of the FAD-Dependent Halogenase RebH Using Directed Evolution.  ChemBioChem. 2014, 15, 1286-1289.

Category: Biocatalysis

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29
Manganese Terpyridine Artificial Metalloenzymes for Benzylic Oxygenation and Olefin Epoxidation

Zhang, C.; Srivastava, P.; Ellis-Guardiola, K.; Lewis, J. C.* Manganese Terpyridine Artificial Metalloenzymes for Benzylic Oxygenation and Olefin Epoxidation. Tetrahedron 2014, 70, 4245-4249.

Category: Artificial Metalloenzymes

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28
Upgrading Nature’s Tools: Expression Enhancement and Preparative Utility of the Halogenase RebH

Payne, J. T.; Lewis, J. C.* Upgrading Nature’s Tools: Expression Enhancement and Preparative Utility of the Halogenase RebH. Synlett 2014, 25, 1345-1349.

Category: Biocatalysis

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27
Ir-Promoted, Pd-catalyzed Direct Arylation of Unactivated Arenes

Durak, L. J. and Lewis, J. C.* Ir-Promoted, Pd-catalyzed Direct Arylation of Unactivated Arenes. Organometallics, 2014, 33, 620-623.

Category: Organometallics

Publication Link


26
A General Method for Artificial Metalloenzyme Formation via Strain-Promoted Azide-Alkyne Cycloaddition

Yang, H.; Srivastava, P.; Zhang, C.; Lewis, J. C.* A General Method for Artificial Metalloenzyme Formation via Strain-Promoted Azide-Alkyne Cycloaddition. ChemBioChem. 2014, 15, 223-227.

Category: Artificial Metalloenzymes

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25
Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis

Lewis, J. C.* Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis. ACS Catal. (invited review) 2013, 3, 2954-2975.

Category: Artificial Metalloenzymes

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24
Transmetallation of Alkyl and Hydride Ligands From Cp*(PMe3)IrR1R2 to (cod)Pt/PdR3X

Durak, L. and Lewis, J. C.* Transmetallation of Alkyl and Hydride Ligands From Cp*(PMe3)IrR1R2 to (cod)Pt/PdR3X. Organometallics. 2013, 32, 3153-3156.

Category: Organometallics

Publication Link


23
Regioselective Arene Halogenation Using the FAD-Dependent Halogenase RebH

Payne, J. T.; Andorfer, M. C.; Lewis, J. C. Regioselective Arene Halogenation Using the FAD-Dependent Halogenase RebH. Angew. Chemie. Int. Ed. 2013, 125, 5379-5382.

Category: Biocatalysis

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22
Synthesis and Catalytic Activity of Amino Acids and Metallopeptides with Catalytically Active Metallocyclic Side Chains

Zhong, Z.; Yang, H.; Zhang, C.; Lewis, J. C. Synthesis and Catalytic Activity of Amino Acids and Metallopeptides with Catalytically Active Metallocyclic Side Chains. Organometallics, 2012, 31, 7328-7331.

Category: Organometallics

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21
Enantioselective Intramolecular C-H amination Catalysed by Engineered Cytochrome P450 Enzymes in vitro and in vivo

McIntosh, J. A.; Coelho, P. S.; Farwell, C. C.; Wang, Z. J.; Lewis, J. C.; Brown, T. R.#; Arnold, F. H.* Enantioselective Intramolecular C-H amination Catalysed by Engineered Cytochrome P450 Enzymes in vitro and in vivo. Angew. Chem. Int. Ed. 2013, 52, 9309 –9312.

Category: Biocatalysis

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20
Synthetic Biology Approaches for Organic Synthesis

“Synthetic Biology Approaches for Organic Synthesis,” P. S. Coelho, J. C. Lewis, F. H. Arnold.* Article 00931 in Comprehensive Organic Synthesis II. G. Molander and P. Knochel (Eds.), Elsevier Ltd: Oxford. 2014, 390-420.

Category: Biocatalysis

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19
Enzymatic Functionalization of Carbon-Hydrogen Bonds

Lewis, J. C.; Coelho, P. S.; Arnold, F. H.* Enzymatic Functionalization of Carbon-Hydrogen Bonds. Chem. Soc. Rev. 2011, 40, 2003-2021.

Category: Biocatalysis

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18
Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates

Lewis, J. C.; Mantovani, S. M.; Fu, Y.; Snow, C. D.; Komor, R. S.; Wong, C. H.; Arnold, F. H.* Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates. ChemBioChem. 2010, 11, 2502-2505.

Category: Biocatalysis

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17
Chemoenzymatic Elaboration of Monosaccharides Using Engineered Cytochrome P450 BM-3 Demethylases

Lewis, J. C.; Bastian, S.; Bennett, C. S.; Fu, Y.; Mitsuda, Y.; Chen, M. M.; Greenberg, W. A.; Wong, C.-H.; Arnold, F. H.* Chemoenzymatic Elaboration of Monosaccharides Using Engineered Cytochrome P450 BM-3 Demethylases. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 16550-16555.

Category: Biocatalysis

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16
Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM-3

Lewis, J. C.; Arnold, F. H.* Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM-3. Chimia 2009, 63, 309-312.

Category: Biocatalysis

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15
Rh(I)-Catalyzed Arylation of Heterocycles via C-H Bond Activation: Expanded Scope Through Mechanistic Insight

Lewis, J. C.; Berman, A. M. Bergman, R. G.*; Ellman, J. A.* Rh(I)-Catalyzed Arylation of Heterocycles via C-H Bond Activation: Expanded Scope Through Mechanistic Insight. J. Am. Chem. Soc. 2008, 130, 2493-2500.

Category: Organometallics

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14
Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines

Berman, A. M.; Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.* Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines. J. Am. Chem. Soc. 2008, 130, 14926-14927.

Category: Organometallics

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13
Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C-H Bond Activation

Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.* Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C-H Bond Activation. Acc. Chem. Res. 2008, 41, 1013-1025.

Category: Organometallics

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12
One-Pot Microwave-Promoted Synthesis of Nitriles from Aldehydes via tert-Butanesulfinyl Imines

Tanuwidjaja, J.#; Peltier, H. M.; Lewis, J. C.; Schenkel, L. B.; Ellman, J. A.* One-Pot Microwave-Promoted Synthesis of Nitriles from Aldehydes via tert-Butanesulfinyl Imines. Synthesis 2007, 3385-3389.

Category: Other

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11
Rh(I)-Catalyzed Alkylation of Quinolines and Pyridines via C-H Activation

Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.* Rh(I)-Catalyzed Alkylation of Quinolines and Pyridines via C-H Activation. J. Am. Chem. Soc. 2007, 129, 5332.

Category: Organometallics

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10
Microwave-Promoted Rhodium-Catalyzed Arylation of Heterocycles via C-H Bond Activation

Lewis, J. C.; Wu, J. Y.#; Bergman, R. G.*; Ellman, J. A.* Microwave-Promoted Rhodium-Catalyzed Arylation of Heterocycles via C-H Bond Activation. Angew. Chem. Int. Ed. 2006, 118, 1619-1621.

Category: Organometallics

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9
Oldfield, E. NMR Shifts, Orbitals, and M...H-X Bonding in d8 Square Planar Metal Complexes

Zhang, Y.; Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.*; Oldfield, E. NMR Shifts, Orbitals, and M...H-X Bonding in d8 Square Planar Metal Complexes. Organometallics 2006, 25, 3515-3519.

Category: Organometallics

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8
Experimental and Computational Studies on the Mechanism of N-Heterocycle C-H Activation by Rh(I)

Wiedemann, S. H.; Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.* Experimental and Computational Studies on the Mechanism of N-Heterocycle C-H Activation by Rh(I). J. Am. Chem. Soc. 2006, 128, 2452-2462.

Category: Organometallics

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7
Preagostic R-H Interactions and C-H Bond Functionalization: A Combined Experimental and Theoretical Investigation of Rh(I) Phosphinite Complexes

Lewis, J. C.; Wu, J. Y.#; Ellman, J. A.*; Bergman, R. G.* Preagostic R-H Interactions and C-H Bond Functionalization: A Combined Experimental and Theoretical Investigation of Rh(I) Phosphinite Complexes. Organometallics 2005, 24, 5737-5746.

Category: Organometallics

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6
Arylation of Heterocycles via Rhodium-catalyzed C-H Bond Functionalization

Lewis, J. C.; Wiedemann, S. H.; Bergman, R. G.*; Ellman, J. A.* Arylation of Heterocycles via Rhodium-catalyzed C-H Bond Functionalization. Org. Lett. 2004, 6, 35-38.

Category: Organometallics

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5
Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1

Souers, A. J.; Wodka, D.; Gao, J.; Lewis, J. C.#; Vasudevan, A.; Gentles, R.; Brodjian, S.; Dayton, B.; Ogiela, C. A.; Fry, D.; Hernandez, L. E.; Marsh, K. C.; Collins, C. A.; Kym, P. R. Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg. Med. Chem. Lett. 2004, 14, 4873-4877.

Category: Chemical Biology

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4
Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3

Souers, A. J.; Wodka, D.; Gao, J.; Lewis, J. C.#; Vasudevan, A.; Brodjian, S.; Dayton, B.; Ogiela, C. A.; Fry, D.; Hernandez, L. E.; Marsh, K. C.; Collins, C. A.; Kym, P. R. Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3. Bioorg. Med. Chem. Lett. 2004, 14, 4883-4886.

Category: Chemical Biology

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3
Effects of Bisphosphonates on the Growth of Entamoeba histolytica and Plasmodium Species in Vitro and in Vivo

Ghosh, S.; Chan, J. M. W.#; Lea, C. R.; Meints, G. A.; Lewis, J. C.#; Tovian, Z. S.#; Flessner, R. M.; Loftus, T. C.#; Bruchhaus, I.; Kendrick, H.; Croft, S. L.; Kemp, R. G.; Kobayashi, S.; Nozaki, T.; Oldfield, E.* Effects of Bisphosphonates on the Growth of Entamoeba histolytica and Plasmodium Species in Vitro and in Vivo. J. Med. Chem. 2004, 47, 175-187.

Category: Chemical Biology

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2
A 3D-QSAR/CoMFA Study of the Activity of Bisphosphonates Against Trypanosoma brucei rhodesiense: Farnesyl Pyrophosphate Synthase as a Drug Target and Analysis of Drug Toxicity

Martin, M. B.; Sanders, J. M.; Kendrick, H.; de Luca-Fradley, K.; Yardley, V.; Lewis, J. C.#; Grimley, J. S.#; van Brussel, E. M.#; Olsen, J. R.#; Meints, G. A.; Burzyska, A.; Kararski, P.; Croft, S. L.; Oldfield, E.* A 3D-QSAR/CoMFA Study of the Activity of Bisphosphonates Against Trypanosoma brucei rhodesiense: Farnesyl Pyrophosphate Synthase as a Drug Target and Analysis of Drug Toxicity. J. Med. Chem. 2002, 45, 2904-2914.

Category: Chemical Biology

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1
Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy

Martin, M. B.; Grimley, J. S.#; Lewis, J. C.#; Heath, H. T. III; Bailey, B. N.; Kendrick, H.; Yardley, V.; Caldera, A.; Lira, R.; Urbina, J. A.; Moreno, S. N. J.; Docampo, R.; Croft, S.; Oldfield, E.* Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy. J. Med. Chem. 2001, 44, 909-916.

Category: Chemical Biology

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Patents

3    Coelho, Pedro, S.; Brustad, Eric M.; Arnold, Frances H.; Wang, Z.; Lewis, Jared C. In vivo and in vitro olefin cyclopropanation catalyzed by engineered and chimeric heme enzyme.” PCT Int. Appl. WO2014058744, 2014.

2    Arnold, F. H.; Wong, C.-H.; Mitsuda, Y.; Chen, M. M.; Bennett, C. S.; Greenberg, W. A.; Lewis, J. C.; Bastian, S. Engineered Bacterial Cytochrome P450 Variants for Preparation of Selectively Protected Carbohydrates. Patent No. US 20090124515, 2009.

1    Collins, C. A.; Gao, J.; Kym, P. R.; Lewis, J. C.; Souers, A. J.; Vasudevan, A.; Wodka, D. 2-Aminoquinolones as Melanin Concentrating Hormone Receptor Antagonists. Patent No. WO 2003105850, 2003.