*corresponding author #undergraduate researcher
Viewing: Artificial Metalloenzymes | See All Publications
74 Non-Native Site-Selective Enzyme Catalysis
Mondal, D.; Snodgrass, H. M.; Gomez, C. A.; Lewis, J. C.* Chem. Rev. 2023, 123, 10381-10431.
See the original preprint available on ChemRxiv.
Category: Artificial Metalloenzymes | Biocatalysis
73 Iridium(III) Polypyridine Artificial Metalloenzymes with Tunable Photophysical Properties: a New Platform for Visible Light Photocatalysis in Aqueous Solution
Liu, B.; Zubi, Y. S.; Lewis, J. C.* Dalton, 2023, 52, 5034-5038.
See the original preprint on ChemRxiv.
Category: Artificial Metalloenzymes
63 Metal-Responsive Regulation of Enzyme Catalysis Using Genetically Encoded Chemical Switches
Zubi, Y. S.; Seki, K.; Li, Y.; Hunt, A.; Liu, B.; Roux, B.*, Jewett, M. C.*, Lewis, J. C.* Nat. Commun. 2022, 13, 1864. Preprint available on ChemRxiv. See peer review here.
Category: Artificial Metalloenzymes | Biocatalysis | Chemical Biology
62 Controlling the Optical and Catalytic Properties of Artificial Metalloenzyme Photocatalysts Using Chemogenetic Engineering
Zubi, Y. S.; Liu, B.; Gu, Y.; Sahoo, D.; Lewis, J. C.* Chem. Sci. 2022, 13, 1459-1468. Preprint available on ChemRxiv.
Category: Artificial Metalloenzymes
59 Engineering Dirhodium Artificial Metalloenzymes for Diazo Coupling Cascade Reactions
Upp, D. M.; Huang, R; Li, Y.; Bultman, M. J.#; Roux, B.*, Lewis, J. C.* Angew. Chem. Int. Ed. 2021, 60, 2-7. You can read the original manuscript on ChemRxiv.
Category: Artificial Metalloenzymes
51 Beyond the Second Coordination Sphere: Engineering Dirhodium Artificial Metalloenzymes to Enable Protein Control of Transition Metal Catalysis
This manuscript was an invited contribution to a special issue of Accounts of Chemical Research on artificial metalloenzyme catalysis and non-native reactions catalyzed by natural metalloenzymes. Check out the rest of the excellent articles here!
Category: Artificial Metalloenzymes
49 Pyrococcus furiosus Prolyl Oligopeptidase: A Dynamic Supramolecular Host for Peptidase and Dirhodium Catalysis
The studies detailed in this manuscript were originally reported on ChemRxiv. The ChemRxiv manuscript detailed how the large scale conformational dynamics outlined in the Biochemistry paper can be used to rationalize the specificity of dirhodium ArMs created from the POP scaffold for cyclopropanation over water O-H insertion. Unfortunately, we were unable to convince reviewers of the latter point, but you can still read about it on ChemRxiv here!
Category: Artificial Metalloenzymes | Biocatalysis
47 Evolving Artificial Metalloenzyme Selectivity via Random Mutagenesis
Yang, H.; Swartz, A. M.; Srivastava, P.; Ellis-Guardiola, K.; Park, H. J.; Upp, D.; Belsare, K.; Lee, G.; Zhang, C.; Moellering, R. E.; Lewis, J. C.* Evolving Artificial Metalloenzyme Selectivity via Random Mutagenesis. Nat. Chem. 2018, 10, 318-324.
Category: Artificial Metalloenzymes
46 Preparation of Artificial Metalloenzymes. In Artificial Metalloenzymes and MetalloDNAzymes in Catalysis. From Design to Applications
Ellis-Guardiola, K.; Lewis, J. C.* Preparation of Artificial Metalloenzymes. In Artificial Metalloenzymes and MetalloDNAzymes in Catalysis. From Design to Applications; Diégues, M.; Bäckvall, J.-E.; Pàmies, O., Eds.; 2018, Wiley-VCH.
Category: Artificial Metalloenzymes
43 Artificial Metalloenzymes: Reaction Scope and Optimization Strategies
Kohler, V.; Schwizer, F.; Okamoto, Y.; Lebrun, V.; Reuter, R.; Pellizzoni, M. M.; Heinisch, T.; Gu, Yifan; Lewis, J. C.*; Ward, T. R.* Artificial Metalloenzymes: Reaction Scope and Optimization Strategies. Chemical Reviews, 2017, 118, 142-231.
Category: Artificial Metalloenzymes
38 Selective C-H Bond Functionalization Using Repurposed or Artificial Metalloenzymes
Upp, D. M.; Lewis, J. C.* Selective C-H Bond Functionalization Using Repurposed or Artificial Metalloenzymes. Curr. Opin. Chem. Biol. 2017, 37, 48-55.
Category: Artificial Metalloenzymes
34 Engineering a Dirhodium Artificial Metalloenzyme for Selective Olefin Cyclopropanation
Srivastava, P.; Yang, H.; Ellis-Guardiola, K.; Lewis, J. C.* Engineering a Dirhodium Artificial Metalloenzyme for Selective Olefin Cyclopropanation. Nat. Commun. 2015, 6, 7789.
Category: Artificial Metalloenzymes
33 Preparation, Characterization, and Reactivity of a Photocatalytic Artificial Enzyme
Gu, Y.; Ellis-Guardiola, K.; Srivastava, P.; Lewis, J. C.* Preparation, Characterization, and Reactivity of a Photocatalytic Artificial Enzyme. ChemBioChem. 2015.
Category: Artificial Metalloenzymes
31 Metallopeptide Catalysts and Artificial Metalloenzymes Containing Unnatural Amino Acids
Lewis, J. C.* Metallopeptide Catalysts and Artificial Metalloenzymes Containing Unnatural Amino Acids. Curr. Opin. Chem. Biol. 2015, 25, 27-35.
Category: Artificial Metalloenzymes
29 Manganese Terpyridine Artificial Metalloenzymes for Benzylic Oxygenation and Olefin Epoxidation
Zhang, C.; Srivastava, P.; Ellis-Guardiola, K.; Lewis, J. C.* Manganese Terpyridine Artificial Metalloenzymes for Benzylic Oxygenation and Olefin Epoxidation. Tetrahedron 2014, 70, 4245-4249.
Category: Artificial Metalloenzymes
26 A General Method for Artificial Metalloenzyme Formation via Strain-Promoted Azide-Alkyne Cycloaddition
Yang, H.; Srivastava, P.; Zhang, C.; Lewis, J. C.* A General Method for Artificial Metalloenzyme Formation via Strain-Promoted Azide-Alkyne Cycloaddition. ChemBioChem. 2014, 15, 223-227.
Category: Artificial Metalloenzymes
25 Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis
Lewis, J. C.* Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis. ACS Catal. (invited review) 2013, 3, 2954-2975.
Category: Artificial Metalloenzymes
Patents
3 Coelho, Pedro, S.; Brustad, Eric M.; Arnold, Frances H.; Wang, Z.; Lewis, Jared C. In vivo and in vitro olefin cyclopropanation catalyzed by engineered and chimeric heme enzyme.” PCT Int. Appl. WO2014058744, 2014.
