Andorfer, M. C.; Lewis, J. C.* Understanding and Improving the Activity of Flavin Dependent Halogenases via Random and Targeted Mutagenesis. Ann. Rev. Biochem. 2018, 87, 159-185.
Andorfer, M. C.; Belsare, K. D.; Girlich, A. M.#; Lewis, J. C.* Aromatic Halogenation Using Bifunctional Flavin Reductase-Halogenase Fusion Enzymes. ChemBioChem, 2017, 18, 2099-2103.
Andorfer, M. C.; Grob, J. E.; Hajdin, C. E.; Chael, J. R.#; Siuti, P.; Lilly, J.; Tan, K. L.*; Lewis, J. C.* Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling. ACS Catalysis. 2017, 7, 1897-1904.
Belsare, K.; Andorfer, M. C.; Cardenas, F.#; Chael, J. R.#; Park, H. J.; Lewis, J. C.* A Simple Combinatorial Codon Mutagenesis Method for Targeted Protein Engineering. ACS Synth. Biol. 2017, 6, 416-420.
Payne, J. T.; Andorfer, M. C.; Lewis, J. C.* Engineering Flavin-Dependent Halogenases. Meth. Enz. 2016, 575, 93-126.
Andorfer, M. C.; Park, H. J.; Vergara-Coll, J.#; Lewis, J. C.* Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds. Chem. Sci. 2016, 7, 3720-3729.
Durak, L. J.; Payne, J. T.; Lewis, J. C.* Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization. ACS Catal. 2016, 6, 1451-1454.
Payne, J. T.; Poor, C. B.; Lewis, J. C.* Directed Evolution of RebH for Site Selective Halogenation of Large, Biologically Active Molecules. Angew. Chem. Int. Ed. 2015, 54, 4226. See a Synfacts comment here.
Poor, C. B.; Andorfer, M. C.; Lewis, J. C.* Improving the Stability of the FAD-Dependent Halogenase RebH Using Directed Evolution. ChemBioChem. 2014, 15, 1286-1289.
Payne, J. T.; Lewis, J. C.* Upgrading Nature’s Tools: Expression Enhancement and Preparative Utility of the Halogenase RebH. Synlett 2014, 25, 1345-1349.