Di-Palladium Complexes are Active Catalysts for Mono-N-Protected Amino Acid Accelerated Enantioselective C-H Functionalization

Gair, J. J.; Haines, B. E.; Filatov, A. S.; Musaev, D. G.*; Lewis, J. C.* Di-Palladium Complexes are Active Catalysts for Mono-N-Protected Amino Acid Accelerated Enantioselective C-H Functionalization. ACS Catalysis, 2019, 9, 11386-11397.

This project originated from efforts to incorporate a Pd-MPAA catalyst into a protein scaffold to generate an ArM. Establishing the identity of such a catalyst proved far more difficult than we expected! The original manuscript, available at ChemRxiv, notes this origin story, which had to be removed during peer review.

TOC Image