Asymmetric Catalysis by Flavin Dependent Halogenases
Jiang, Y.; Lewis, J. C.* Submitted. Preprint available on ChemRxiv.
Archives
Directed Evolution of a Fe(II)- and alpha-Ketoglutarate-Dependent Dioxygenase for Site-Selective Azidation of Unactivated Aliphatic C-H Bonds
Gomez, C.; Mondal, D.; Du, Q.; Chan, N.; Lewis, J. C.* Submitted. Preprint available on ChemRxiv.
First and Second Sphere Interactions Accelerate Non-Native N-Alkylation Catalysis by the Thermostable, Methanol-Tolerant B12-Dependent Enzyme MtaC.
Kumar, A.; Yang, X., Li, J.; Lewis, J. C.* Submitted. Preprint available on ChemRxiv.
The Single Component Flavin Reductase/Flavin Dependent Halogenase AetF is a Versatile Catalyst for Selective Bromination and Iodination of Arenes and Olefins
Jiang, Y.; Snodgrass, H. M.; Zubi, Y. S.; Roof, C. V.; Guan, Y.; Mondal, D.; Honeycutt, N. H.#; Lee, J.; Lewis, R. D.; Martinez, C. A.; Lewis, J. C.* See the original manuscript on ChemRxiv.
Expanding the Reactivity of Flavin Dependent Halogenases Toward Olefins via Enantioselective Intramolecular Haloetherification and Chemoenzymatic Oxidative Rearrangements
Jiang, Y.; Mondal, D.; Lewis, J. C.* ACS Catalysis, 2022, 12, 13501-13505. Check out the original manuscript on ChemRxiv.
Non-native Anionic Ligand Binding and Reactivity in Engineered Variants of the Fe(II)- and α-Ketoglutarate-Dependent Oxygenase, SadA
Chan, N. H.; Gomez, C.; Vennelakanti, V.; Du, Q.; Kulik, H. J.*; Lewis, J. C.* Inorg. Chem. 2022, 61, 14477-14485. Check out the original manuscript on ChemRxiv.
Directed Evolution of Flavin-Dependent Halogenases for Atroposelective Halogenation of 3-Aryl-4(3H)-quinazolinones via Kinetic or Dynamic Kinetic Resolution
Snodgrass, H. M.; Mondal, D.; Lewis, J. C.* J. Am. Chem. Soc. 2022, 144, 16676-16682.. See the original manuscript on ChemRxiv.
Analysis of Laboratory-Evolved Flavin-Dependent Halogenases Affords a Computational Model for Predicting Halogenase Site Selectivity
Andorfer, M. C.; Evans, D.; Yang, S. He, C. Q.; Girlich, A. M.#; Vergara-Coll, J.#; Sukumar, N.; Houk, K. N.*; Lewis, J. C.* Chem. Catal. 2022, 2, 2658-2674. Check out the original manuscript on ChemRxiv.
Metal-Responsive Regulation of Enzyme Catalysis Using Genetically Encoded Chemical Switches
Zubi, Y. S.; Seki, K.; Li, Y.; Hunt, A.; Liu, B.; Roux, B.*, Jewett, M. C.*, Lewis, J. C.* Nat. Commun. 2022, 13, 1864. Preprint available on ChemRxiv. See peer review here.
Controlling Non-Native B12 Reactivity and Catalysis in the Transcription Factor CarH
Yang, X.; Gerroll, B. H. R.; Jiang, Y.; Kumar, A.; Zubi, Y. S.; Baker, L. A.; Lewis, J. C.* ACS Catal. 2022, 12, 935-942. Preprint available on ChemRxiv.
